Dissociable effects of CBD and cannabis on the brain

Seventeen people underwent three drug treatments and scanning sessions. Treatments were cannabis containing THC, cannabis containing THC with CBD, and matched placebo cannabis. Seed-based resting-state functional connectivity analyses were performed on three brain networks: the default mode (DMN; defined by positive connectivity with the posterior cingulate cortex: PCC+), executive control (ECN; defined by negative connectivity with the posterior cingulate cortex: PCC-) and salience (SAL; defined by positive connectivity with the anterior insula: AI+) network.

Reductions in functional connectivity (relative to placebo) were seen in the DMN (PCC+) and SAL (AI+) networks for both strains of cannabis, with spatially dissociable effects. Across the entire salience network (AI+), Cann-CBD reduced connectivity relative to Cann+CBD. The PCC in the DMN was specifically disrupted by Cann-CBD, and this effect correlated with subjective drug effects, including feeling 'stoned' and 'high'.

THC disrupts the DMN, and the PCC is a key brain region involved in the subjective experience of THC intoxication. CBD restores disruption of the salience network by THC, which may explain its potential to treat disorders of salience such as psychosis and addiction.


FDA Disclaimers apply to our products. This information is for general purposes only.

Older Post
Newer Post

Leave a comment

Please note, comments must be approved before they are published

Close (esc)


Shop the best, natural Veteran Owned CBD and follow @uncanna on social. We appreciate your support!


Age verification

By clicking enter you are verifying that you are old enough to consume alcohol.


Main menu

Shopping Cart

Your cart is currently empty.
Shop now