Drug screening for CBD/THC
Oct 24, 2021
DRUG SCREENING | CBD
Although research laboratories can test specifically for CBD, we have not seen or heard of specific testing for CBD being used in employment scenarios. Given all of what you have learned thus far, it does not make much sense to drug test for a substance that is federally legal and will be available nationwide next to other vitamins and supplements soon.
With that being said, we have found some interesting studies in regards to urinalyses and CBD. The important thing to remember is that urinalyses are testing for the compound THC to look for marijuana use. This means that you are absolutely taking a risk if you are using any whole plant or full spectrum product, regardless of claims or potency. The World health Organization was trying to determine if someone could take CBD Isolate and turn it into THC, which is currently an illegal drug. Here is what they found.'
It has been proposed that the conversion of CBD to delta-9-THC in the presence of acid could occur in the human gut. Such conversion could be of importance if CBD is administered orally. Two in vitro studies have used simulated gastric fluid to demonstrate the potential for this conversion. The first reported the formation of analytically confirmed delta-9-THC and delta-8-THC when CBD was exposed to simulated gastric fluid without enzymes at 37ºC. The authors concluded that that the acidic environment during normal gastrointestinal transit could expose orally administered CBD.
The second in vitro study also reported the formation of delta-9-THC along with other cannabinoid products in artificial gastric juice without pepsin. The conversion rate of CBD to THC was only 2.9%. 
The predictive value of these in vitro studies for humans administering cannabidiol orally has been questioned as simulated gastric fluid does not exactly replicate physiological conditions in the stomach. Furthermore, spontaneous conversion of CBD to delta-9-THC has not been demonstrated in humans undergoing CBD treatment. For example, in a six week clinical study in Huntington’s disease patients who were administered CBD 700 mg/day, the CBD average plasma concentration range was 5.9-11.2 ng/mL with no delta-9-THC detected.
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