ABOUT THIS GUIDE
The purpose of this guide is to educate people on all aspects of CBD, so that they become advocates themselves, armed with the knowledge to intelligently discuss the subject, or to confidently purchase and use CBD products.
The information here is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content contained on or available through UnCanna platforms or provided by our customer service team is for general information purposes only. We are unable to provide treatment statements or dosing recommendations at this time, due to FDA regulations.
HEMP | MARIJUANA | CANNABIS
Are Hemp and Marijuana the Same? No, but they are both part of the Cannabis family. Hemp is completely different from marijuana in its function, cultivation and application. Marijuana is used for medicinal or recreational purposes. Hemp is used in a variety of other applications. These include supplements, skin products, clothing, construction materials, paper products, sustainable fuel and food sources, and accessories . Overall, hemp is known to have over 25,000 possible applications in every industry from lumber to pharma.
Can You Get “High” Off Hemp? “Your lungs would fail before your brain attains any high from smoking industrial hemp” is a common response to this question.
The main difference is the chemical compositions, specifically in tetrahydrocannabinol (THC). THC is the chemical responsible for marijuana’s psychological effects. Marijuana contains anywhere from 5-20% THC content on average. "Premium" marijuana can have up to 25-30% THC. Hemp has a max THC level of 0.3%, essentially making it impossible to feel any psychoactive effect or get a “high”. Hemp also has high cannabidiol (CBD) content that is scientifically proven to act as THC’s antagonist.
How Hemp got grouped in with Marijuana and made illegal, until 20 December 2018 thanks to the 2018 Farm Bill. President Nixon declares war on cannabis. In the 1970s, President Nixon declared a “War on Drugs” and signed into law the United States Controlled Substances Act of 1970 (US CSA). This law established a set of banned drugs and created the Drug Enforcement Administration (DE A). It also unintentionally outlawed one of the world’s oldest domesticated crop, hemp. This not only led to the demise of hemp, but also an increased misconception of the plant.
In the Controlled Substances Act, hemp was grouped with marijuana and made illegal to grow in the US. This, unfortunately, classified hemp as a drug even though it doesn’t include high enough amounts of THC to have the "high" psychoactive effects, which is why Marijuana is classified as a drug. The 2018 Farm Bill was signed on 20 December 2018 and permanently removed hemp from the CSA. The FDA has full regulatory authority of CBD and is expected to regulate it as any natural vitamin, but some states have CBD specific laws despite the announcement of the historic Farm Bill news.
Source: Ministry of Hemp | PUBMED.GOV
A summary by the World Health Organization (WHO)
Cannabidiol (CBD) is one of the naturally occurring cannabinoids found in cannabis plants. It is a 21-carbon terpenophenolic compound which is formed following decarboxylation from a cannabidiolic acid precursor, although it can also be produced synthetically.
Cannabidiol is not listed in the schedules of the 1961, 1971, 1988 United Nations International Drug Control Conventions or in the United States Controlled Substances Act (US CSA).
In humans, CBD exhibits no effects indicative of any abuse or dependence potential. To date, there is no evidence of recreational use of CBD or any public health related problems associated with the use of pure CBD.
CBD has been demonstrated as an effective treatment of epilepsy in several clinical trials. There is also preliminary evidence that CBD may be a useful treatment for a number of other medical conditions.
CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications. As noted above, CBD does not produce the effects that are typically seen with cannabinoids such as THC. It also failed to produce significant effects in a human study of abuse potential.
SOURCE: The World Health Organization
We make no claims in regards to our products. Please view our FDA Disclaimer here.
SEARCH "CANNABIDIOL" AND "CANNABINOIDS"
VIA THE LINKS BELOW
We do not make treatment statements or claims in regards to our products IAW FDA Regulations. We highly encourage you to conduct your own research at the following websites or view our compilation of articles on the UnCanna Blog
MECHANISM OF ACTION
HOW CBD WORKS
CBD may also interact with the endocannabinoid system through indirect mechanisms such as enhanced action of the endogenous cannabinoid ligand anandamide. This results from blockade of anandamide reuptake and the inhibition of its enzymatic degradation.
CBD has been shown to modulate several non-endocannabinoid signaling systems. It is not clear which, if any, of these mechanisms are responsible for any of CBD’s potential clinical or other effects. Some of these mechanism include: Inhibition of adenosine uptake, possibly resulting in indirect agonist activity at adenosine receptors. Enhanced activity at the 5-HT1a receptor. Enhanced activity at glycine receptor subtypes Blockade of the orphan G-protein-coupled receptor GPR55
IS CBD SAFE TO USE
SOURCE: World Health Organization
"CBD does not produce the effects that are typically seen with cannabinoids such as THC. It also failed to produce significant effects in a human study of abuse potential discussed below. Across a number of controlled and open label trials CBD of the potential therapeutic effects of CBD it is generally well tolerated, with a good safety profile."
KNOWN AND POTENTIAL SIDE EFFECTS OF CBD
- Effects on the immune system are unclear; there is evidence of immune suppression at higher concentrations, but immune stimulation may occur at lower concentrations.
- There is potential for CBD to be associated with drug interactions through inhibition of some cytochrome P450 enzymes, but it is not yet clear whether these effects occur at physiological concentrations.
- In contrast to THC, CBD has no effect on heart rate or blood pressure under normal conditions, but in animal models of stress it reduces heart rate and blood pressure.
- CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications.
There are many ways to process CBD products, each has its pros and cons. Some methods are safer and more effective than others. Our extraction process consists of using state of the art, food-grade processing equipment. The Supercritical CO2 and Ethanol Extraction methods are used to develop our products,. These are techniques and equipment that is widely used in the food industry.
The supercritical (or sub-critical) CO2 method uses carbon dioxide under high pressure and extremely low temperatures to isolate, preserve, and maintain the purity of the oil. This process requires expensive equipment and a steep operational learning curve. But, when done well the end product is safe, potent, and free of chlorophyll. Watch a quick video here.
High-grade grain alcohol can be used to create high-quality cannabis oil appropriate for vape pen cartridges and other products. Watch a quick video here.
The FDA is expected to announce regulations concerning hemp-derived CBD products. We are ahead of the regulatory power curve, along with many other industry leading CBD brands.
With that being said, there are many bad actors within this space. There is a massive amount of CBD products developed from raw materials shipped from overseas. There have also been cases of "third party lab" testing facilities forging their results in favor of making sales with inaccurate information such as a higher concentration, no pesticides, etc. Some of the industry standards, regulatory requirements, and things to look for are located below.
- USDA Certified Organic or organic growing practices used (hemp source)
- GRAS (not yet applicable to CBD products)
- FDA Compliant labels i.e. supplement facts, FDA disclaimer, directions, manufacturer information, all ingredients, etc. (if it looks sketchy, it probably is sketchy)
- Third-party independent lab testing, with visible lab results
- 30ml dropper bottles/standard serving sizes
- Normal payment processing services i.e. you can checkout the same as any other online store
- Numerous contact methods/business address i.e. can I speak to a real person
- Reviews from real people
VARIOUS CBD TERMINOLOGY
It is important to understand the varieties and uses of the term "CBD". CBD is the abbreviation for Cannabidiol, technically. However, your CBD product could be Full Spectrum, Broad Spectrum, or Isolate. Also, there are "hemp oils" available such as the ones you see on Walmart shelves and although they are a healthy food source, it is not the CBD oil you are looking for. There are many different terms thrown around by companies in the industry, to include "phytocannabinoid rich hemp extract", "hemp extract", and simply "CBD oil" or "hemp supplement".
The important thing is to determine whether you want to use THC-Free (Isolate/Broad Spectrum) or Whole Plant (Full Spectrum) products, then verify the potency and purity of that product via certificates of analyses from third-party labs, verify the industry standards we previously discussed here, and then place an order. We suggest adjusting your dosing and trying different types/brands to find what works best for your needs.
TYPES OF CBD
FULL SPECTRUM CBD
Contains all naturally occurring cannabinoids, terpenes, flavinoids, and vitamins found in the hemp strain processed. Contains less than .3% THC, verified by certificates of analyses. Although this is a trace amount of THC, that will not get you "high", you should not use these products if subjected to drug screening for THC and care about your career or job, because these products have a chance of showing a positive result for THC.
BROAD SPECTRUM CBD
Broad Spectrum CBD products contain all naturally occurring cannabinoids, terpenes, flavinoids, and vitamins as Full Spectrum, except without the trace levels of THC. This is because the Broad Spectrum product undergoes an additional process to remove the remaining THC content.
Isolate CBD is exactly that, isolated Cannabidiol. Quality Isolate is usually 99+% pure, verified via third party certificates of analyses. These products do not contain any other compound, to include THC.
DRUG SCREENING | CBD
Although research laboratories can test specifically for CBD, we have not seen or heard of specific testing for CBD being used in employment scenarios. Given all of what you have learned thus far, it does not make much sense to drug test for a substance that is federally legal and will be available nationwide next to other vitamins and supplements soon.
With that being said, we have found some interesting studies in regards to urinalyses and CBD. The important thing to remember is that urinalyses are testing for the compound THC to look for marijuana use. This means that you are absolutely taking a risk if you are using any whole plant or full spectrum product, regardless of claims or potency. The World health Organization was trying to determine if someone could take CBD Isolate and turn it into THC, which is currently an illegal drug. Here is what they found.'
It has been proposed that the conversion of CBD to delta-9-THC in the presence of acid could occur in the human gut. Such conversion could be of importance if CBD is administered orally. Two in vitro studies have used simulated gastric fluid to demonstrate the potential for this conversion. The first reported the formation of analytically confirmed delta-9-THC and delta-8-THC when CBD was exposed to simulated gastric fluid without enzymes at 37ºC. The authors concluded that that the acidic environment during normal gastrointestinal transit could expose orally administered CBD.
The second in vitro study also reported the formation of delta-9-THC along with other cannabinoid products in artificial gastric juice without pepsin. The conversion rate of CBD to THC was only 2.9%. 
The predictive value of these in vitro studies for humans administering cannabidiol orally has been questioned as simulated gastric fluid does not exactly replicate physiological conditions in the stomach. Furthermore, spontaneous conversion of CBD to delta-9-THC has not been demonstrated in humans undergoing CBD treatment. For example, in a six week clinical study in Huntington’s disease patients who were administered CBD 700 mg/day, the CBD average plasma concentration range was 5.9-11.2 ng/mL with no delta-9-THC detected.
More on this topic here -> Read this
UnCanna THC Free products have No Detectable (ND) levels of THC, verified via third-party certificates of analyses and visible in the product photos.
METHODS OF USE
- Oil drops or tinctures taken sublingual or mixed with beverage/food
- Softgels taken orally
- Salve applied topically
- Isolate powder can be vaporized, taken sublingual, or mixed with food/beverage/oil
- Dog Treats
- Edibles ie gummies, etc.
*Beware of gimmick products in this industry