ABOUT THIS GUIDE
The purpose of this guide is to educate our community on various aspects of CBD, so that they become advocates themselves, armed with the knowledge to intelligently discuss the subject, advocate for use in lieu of dangerous alternatives ie prescription drugs, and to confidently purchase and implement CBD products as a daily supplement.
The information here is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content contained on or available through UnCanna platforms or provided by our customer service team is for general information purposes only. We are unable to provide treatment statements or dosing recommendations at this time, due to FDA regulations.
WHAT IS CBD?
Hemp plants contain 113+ naturally occurring active compounds known as cannabinoids. Cannabidiol (CBD) is one of the major cannabinoids found in the hemp and marijuana variations of cannabis. THC is the most commonly known cannabinoid, but unlike THC, CBD is non-intoxicating.
A summary by the World Health Organization (WHO)
Cannabidiol (CBD) is one of the naturally occurring cannabinoids found in cannabis plants. It is a 21-carbon terpenophenolic compound which is formed following decarboxylation from a cannabidiolic acid precursor, although it can also be produced synthetically.
In humans, CBD exhibits no effects indicative of any abuse or dependence potential. To date, there is no evidence of recreational use of CBD or any public health related problems associated with the use of pure CBD.
CBD has been demonstrated as an effective treatment of epilepsy in several clinical trials. There is also preliminary evidence that CBD may be a useful treatment for a number of other medical conditions.
CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications. As noted above, CBD does not produce the effects that are typically seen with cannabinoids such as THC. It also failed to produce significant effects in a human study of abuse potential.
HEMP | MARIJUANA | CANNABIS
UNDERSTAND THE DIFFERENCE
Are Hemp and Marijuana the Same? No, but they are both part of the Cannabis family. Hemp is completely different from marijuana in its function, cultivation and application. Marijuana is used for medicinal or recreational purposes. Hemp is used in a variety of other applications. These include supplements, skin products, clothing, construction materials, paper products, sustainable fuel and food sources, and accessories . Overall, hemp is known to have over 25,000 possible applications in every industry from lumber to pharma.
Can You Get “High” Off Hemp? “Your lungs would fail before your brain attains any high from smoking industrial hemp” is a common response to this question.
The main difference is the chemical compositions, specifically in tetrahydrocannabinol (THC). THC is the chemical responsible for marijuana’s psychological effects. Marijuana contains anywhere from 5-20% THC content on average. "Premium" marijuana can have up to 25-30% THC. Hemp has a max THC level of 0.3%, essentially making it impossible to feel any psychoactive effect or get a “high”. Hemp also has high cannabidiol (CBD) content that is scientifically proven to act as THC’s antagonist.
How Hemp got grouped in with Marijuana and made illegal, until 20 December 2018 thanks to the 2018 Farm Bill. President Nixon declares war on cannabis. In the 1970s, President Nixon declared a “War on Drugs” and signed into law the United States Controlled Substances Act of 1970 (US CSA). This law established a set of banned drugs and created the Drug Enforcement Administration (DE A). It also unintentionally outlawed one of the world’s oldest domesticated crop, hemp. This not only led to the demise of hemp, but also an increased misconception of the plant.
In the Controlled Substances Act (CSA), hemp was grouped with marijuana and made illegal to grow in the US. This unfortunately classified hemp as a drug even though it doesn’t include high enough amounts of THC to have the "high" psychoactive effects, which is why Marijuana is classified as a drug. The 2018 Farm Bill was signed on 20 December 2018 and permanently removed hemp from the CSA.
According to the Federal Government, industrial hemp includes the plant Cannabis Sativa L. and any part or derivative with a THC concentration of no more than 0.3 percent on a dry weight basis. (81 FR 53395)
0.3% is the magic number laid out by Section 7606 of the Farm Bill, all CBD products manufactured by UnCanna are derived from crops grown in accordance with Section 7606 of the Farm Bill.
Trace amounts of THC are not enough to cause intoxication, even if large amounts are ingested. CBD from hemp provides endocannabinoid system support without the high of marijuana.
HOW DOES CBD WORK?
THE ENDOCANNABINOID SYSTEM
Your Endocannabinoid System is a network of messengers and receptors that regulate the way your body functions, a communication system between your body and brain. The messengers, called cannabinoids, bind with the receptors located throughout your body.
The cannabinoids made in your body are called endocannabinoids. Although your body creates cannabinoids (2-AG and anandamide) as needed, they are quickly broken down by enzymes and that is where CBD can benefit you.
Like a daily vitamin, CBD supplements the endocannabinoid system, which plays a vital role in optimal human performance.
The Endocannabinoid System regulates: Sleep, Appetite, Mood, Motor Control, Immune Function, Pleasure, Pain, Reproduction, Fertility, Memory, and Temperature.
CBD may also interact with the endocannabinoid system through indirect mechanisms such as enhanced action of the endogenous cannabinoid ligand anandamide. This results from blockade of anandamide reuptake and the inhibition of its enzymatic degradation.
CBD has been shown to modulate several non-endocannabinoid signaling systems. It is not clear which, if any, of these mechanisms are responsible for any of CBD’s potential clinical or other effects. Some of these mechanism include: Inhibition of adenosine uptake, possibly resulting in indirect agonist activity at adenosine receptors. Enhanced activity at the 5-HT1a receptor. Enhanced activity at glycine receptor subtypes Blockade of the orphan G-protein-coupled receptor GPR55.
IS CBD SAFE TO USE?
SOURCE: World Health Organization
"CBD does not produce the effects that are typically seen with cannabinoids such as THC. It also failed to produce significant effects in a human study of abuse potential discussed below. Across a number of controlled and open label trials CBD of the potential therapeutic effects of CBD it is generally well tolerated, with a good safety profile."
KNOWN AND POTENTIAL SIDE EFFECTS OF CBD
- Effects on the immune system are unclear; there is evidence of immune suppression at higher concentrations, but immune stimulation may occur at lower concentrations.
- There is potential for CBD to be associated with drug interactions through inhibition of some cytochrome P450 enzymes, but it is not yet clear whether these effects occur at physiological concentrations.
- In contrast to THC, CBD has no effect on heart rate or blood pressure under normal conditions, but in animal models of stress it reduces heart rate and blood pressure.
- CBD is generally well tolerated with a good safety profile. Reported adverse effects may be as a result of drug-drug interactions between CBD and patients’ existing medications.
CAN I TAKE CBD WITH PRESCRIPTION MEDICATIONS?
As with any supplement, we recommend consulting your physician prior to adding CBD to your daily routine. There are studies that show the implications of using CBD in conjunction with prescription medications, namely increasing or decreasing the efficacy of the medicine, which could be dangerous.
Please view this article for in-depth information.
DIFFERENT TYPES OF CBD
FULL SPECTRUM CBD
Contains all naturally occurring cannabinoids, terpenes, flavinoids, and vitamins found in the hemp strain processed. Contains less than .3% THC, verified by certificates of analyses. Although this is a trace amount of THC, that will not get you "high", you should not use these products if subjected to drug screening for THC and care about your career or job, because these products have a chance of showing a positive result for THC.
BROAD SPECTRUM CBD
Broad Spectrum CBD products contain all naturally occurring cannabinoids, terpenes, flavinoids, and vitamins as Full Spectrum, except without the trace levels of THC. This is because the Broad Spectrum product undergoes an additional process to remove the remaining THC content.
Isolate CBD is exactly that, isolated Cannabidiol. Quality Isolate is usually 99+% pure, verified via third party certificates of analyses. These products do not contain any other compound, to include THC.
Cannabinol (CBN) is a minor cannabinoid, meaning there are very little amounts that naturally occur and it takes more hemp biomass to extract enough CBN to formulate various products hence why it is more expensive than CBD Isolate. CBN is known to help with sleep issues, and provide a physical effect that may relieve pain. Although third party lab results show No Detectable (ND) levels of THC in CBN products, they do contain a trace amount of Delta-8 THC and we would highly advise you DO NOT use CBN products if subjected to urinalyses screening for THC.
CBN has also shown potential as a treatment for sleep disorders, pain relief, and inflammation, among other medical benefits. For instance, in an analysis shared by Steep Hill Labs in 2017, researchers found that a 2.5-to-5 milligram dose of CBN was as effective as a 5-to-10 milligram dose of the pharmaceutical sedative diazepam.
DELTA-8 THC vs DELTA-9 THC
You know of THC, which is Delta-9 THC, but what about Delta-8 THC?
Delta-8-tetrahydrocannabinol (delta-8-THC, Δ8-THC) is a psychoactive cannabinoid found in the Cannabis plant. It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ9-THC), the compound commonly known as THC. Delta-8 is a cannabis compound that has become popular because of its similarity to delta-9 THC, the main compound in cannabis that gets you high. Delta-8 has been growing in popularity, especially in states that have not yet legalized recreational marijuana use.
Delta-8 can give people a high, while not as potent as delta-9 THC. Consumers report many of the same effects as THC, such as euphoria, happiness, uplifting feelings, and relief from some symptoms including pain. Resulting in this “legal” drug acting like the illegal delta-9. Side effects may also be similar to those of THC, including dry mouth, red eyes, short-term memory loss, paranoia, and anxiety.
Since delta-8 is similar to delta-9 in chemical structure and the side effects it produces, delta-8 also responds to drug tests in the same way. Your body will retain its metabolites for some time. The metabolites produced by delta-8 are the same as those produced by delta-9 THC. The primary non-active metabolite that delta-8 THC gets reduced to in the body is 11-Nor-9-carboxy THC or THC-COOH. These lipid-soluble metabolites do not get flushed out of your body easily and can linger in the body like any other THC and may be detected by a drug test. As with all substances, the amount of time delta-8 will remain detectable varies from person to person. When testing a cross-reaction can occur with delta-8 and the THC strip on a rapid oral fluid drug test.
Colorado regulators banned hemp-derived THC isomers such as delta-8 in foods, drinks and dietary supplements. A notice issued by the Colorado health department says that “chemically modifying or converting any naturally occurring cannabinoids from industrial hemp is non-compliant with the statutory definition of ‘industrial hemp product.’”
UnCanna does not manufacture or sell Delta-8 THC, although trace amounts naturally occur in Cannabinol (CBN) products, which we do manufacture and sell.
DRUG TESTING & CBD
Although research laboratories can test specifically for CBD, we have not seen or heard of specific testing for CBD being used in employment scenarios. Given all of what you have learned thus far, it does not make much sense to drug test for a substance that is federally legal and will be available nationwide next to other vitamins and supplements soon.
With that being said, we have found some interesting studies in regards to urinalyses and CBD. The important thing to remember is that urinalyses are testing for the compound THC to look for marijuana use. This means that you are absolutely taking a risk if you are using any whole plant or full spectrum product, regardless of claims or potency. The World health Organization was trying to determine if someone could take CBD Isolate and turn it into THC, which is currently an illegal drug. Here is what they found.'
It has been proposed that the conversion of CBD to delta-9-THC in the presence of acid could occur in the human gut. Such conversion could be of importance if CBD is administered orally. Two in vitro studies have used simulated gastric fluid to demonstrate the potential for this conversion. The first reported the formation of analytically confirmed delta-9-THC and delta-8-THC when CBD was exposed to simulated gastric fluid without enzymes at 37ºC. The authors concluded that that the acidic environment during normal gastrointestinal transit could expose orally administered CBD.
The second in vitro study also reported the formation of delta-9-THC along with other cannabinoid products in artificial gastric juice without pepsin. The conversion rate of CBD to THC was only 2.9%. 
The predictive value of these in vitro studies for humans administering cannabidiol orally has been questioned as simulated gastric fluid does not exactly replicate physiological conditions in the stomach. Furthermore, spontaneous conversion of CBD to delta-9-THC has not been demonstrated in humans undergoing CBD treatment. For example, in a six week clinical study in Huntington’s disease patients who were administered CBD 700 mg/day, the CBD average plasma concentration range was 5.9-11.2 ng/mL with no delta-9-THC detected.
More on this topic here -> Read this
CAN I FAIL A DRUG TEST FOR THC WHEN USING FULL SPECTRUM TOPICAL CBD PRODUCTS?
With topical applications, it is highly unlikely for any amount of THC to be absorbed and metabolized by the body and detected in a drug test UNLESS you are using penetration enhancers, transdermal patches, or there's a higher level of THC than federally permitted in the product.
UnCanna THC Free products have No Detectable (ND) levels of THC, verified via third-party certificates of analyses and visible in the product photos.
VARIOUS CBD TERMINOLOGY
It is important to understand the varieties and uses of the term "CBD". CBD is the abbreviation for Cannabidiol, technically. However, your CBD product could be Full Spectrum, Broad Spectrum, or Isolate. Also, there are "hemp oils" available such as the ones you see on Walmart shelves and although they are a healthy food source, it is not the CBD oil you are looking for. There are many different terms thrown around by companies in the industry, to include "phytocannabinoid rich hemp extract", "hemp extract", and simply "CBD oil" or "hemp supplement".
The important thing is to determine whether you want to use THC-Free (Isolate/Broad Spectrum) or Whole Plant (Full Spectrum) products, then verify the potency and purity of that product via certificates of analyses from third-party labs, verify the industry standards we previously discussed here, and then place an order. We suggest adjusting your dosing and trying different types/brands to find what works best for your needs.
The FDA is expected to announce regulations concerning hemp-derived CBD products. We are ahead of the regulatory power curve, along with many other industry leading CBD brands.
With that being said, there are many bad actors within this space. There is a massive amount of CBD products developed from raw materials shipped from overseas. There have also been cases of "third party lab" testing facilities forging their results in favor of making sales with inaccurate information such as a higher concentration, no pesticides, etc. Some of the industry standards, regulatory requirements, and things to look for are located below.
- ISO9001 certified manufacturing facilities
- cGMP manufacturing facilities
- USDA Certified Organic or organic growing practices used (hemp source)
- FDA Compliant labels i.e. supplement facts, FDA disclaimer, directions, manufacturer information, all ingredients, etc. (Colorado State regulates label info)
- Hemp Industry Trade Association Affiliations (HIA/NHA)
- Third-party independent lab testing, with visible lab results
- 30ml dropper bottles/standard serving sizes
- Normal payment processing services i.e. you can checkout the same as any other online store
- Numerous contact methods/business address i.e. can I speak to a real person
- Verified reviews from real people
- Full Spectrum oil is gold, Broad Spectrum extract is light gold, and Isolate oil is clear in tincture form.
HOW TO CHOOSE A CBD PRODUCT TYPE
1. Determine if you can use trace amounts of THC, less than .3% which is Farm Bill Compliant and federally legal, or if you cannot use any THC.
2. If you are comfortable with a trace, non-intoxicating amount of THC, we recommend our Full Spectrum CBD products. These provide the entourage effect, where all the plant compounds work together in synergy. They are better reviewed and our best selling products.
3. If you cannot use THC, look into using a THC-Free product. This would be any CBD product from our Isolate and Broad Spectrum collections.
4. Oil Tinctures and Softgels, Isolate powders, as well as edibles typically have a whole body effect and many report a noticeable change in mood, anxiety, being calm, etc. whereas topical CBD products will have a direct effect on the target area where the topical is applied ie use topical for muscles/joints and use an oil tincture/softgels/edibles for whole body and mindset.
CBD Isolate is what is primarily seen in the industry, and by consumers. This is isolated Cannabidiol (CBD), and does not contain any other plant compounds. These products will lack the entourage effect, but many people prefer to use Isolate CBD and the feedback is positive. These products do not contain any detectable (ND) levels of THC.
Broad Spectrum CBD is considered better than Isolate CBD because it provides the entourage effect, with the exception of THC. These products do not contain any detectable (ND) levels of THC.
WHAT DOSE SHOULD I TAKE FOR X CONDITION?
We cannot legally recommend dosing for any conditions due to FDA regulations.
The majority of our customers (180lb+) are taking ~30mg 1-2x daily and have offered positive reviews, with customers (180lb-) taking ~20mg 1-2x daily with positive feedback. This feedback can be found in our reviews on site.
There are many articles online that recommend different dosage requirements for specific ailments or symptoms that you are trying to target. We recommend researching these articles to facilitate an educated decision so that you take the correct amount without wasting your product or taking too little.
Bottom line, everyone processes CBD differently and it takes trials to determine what dose works best for you. Start with a low dose and increase gradually on subsequent doses until desired effects are achieved. This will save you product ie money and help you better determine which products fit your needs.
You may need a little patience to determine the optimal daily dosage to suit your needs. Your body is unique, a dosage that works well for someone else may be too much or too little for you. While there is no danger in taking more CBD than you need, it has been found that more CBD does not necessarily improve your results, and increases your costs.
While CBD manufacturers typically do not suggest dosage information, some sources suggest starting at a low dose, (10-20mg) per day, while assessing your results.
When trying to determine your ideal dosage for your purposes, if you do not experience the results you are looking for after 3-4 hours; you can increase the amount of CBD taken with your next dose. Eventually, you will find the best dose of CBD for your needs.
**FDA Disclaimer on home page and below. This information is for general purposes only.
SEARCH "CANNABIDIOL" AND "CANNABINOIDS" VIA THE LINKS BELOW
We do not make treatment statements or claims in regards to our products IAW FDA Regulations. We highly encourage you to conduct your own research at the following websites or view our compilation of articles on the UnCanna Blog
Some of the best sources for more information and research regarding cannabinoids are pubmed.gov and projectcbd.org. Many brands will pretend to be experts but their info comes from these two sources.